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The CLARIOstar is a multi-mode microplate reader with advanced LVF Monochromators™, highly sensitive filters, and an ultra-fast UV/vis spectrometer. It is a modular microplate reader with up to seven different detection modes: fluorescence intensity (incl. FRET), fluorescence polarization, luminescence (including BRET), UV/vis absorbance, time-resolved fluorescence, TR-FRET, and AlphaScreen®/AlphaLISA®/AlphaPlex™.


  • Innovative monochromators for increased sensitivity
  • Fully-flexible wavelengths and bandwidths
  • Spectral scanning in AS, FI and LUM
  • Higher light transmission
  • High-speed absorbance measurements
  • Dedicated laser for Alpha Technology
  • Live cell-based assays
  • Low volume measurements





  • Detection Modes

    Fluorescence intensity (incl. FRET)

    Fluorescence polarization 


    Luminescence (flash and glow) - incl. BRET

    Time-resolved fluorescence


    UV/Vis absorbance spectra

  • Measurement Modes

    Top and bottom reading

    Endpoint and kinetic

    Sequential multi-excitation

    Sequential multi-emission

    Spectral scanning (fluorescence, luminescence, absorbance)

    Ratiometric measurements

    Well scanning

  • Microplate Formats

    6- to 1536-well plates, user-definable

    LVis Plate with 16 low volume microspots (2 μL)

  • Microplate Carrier

    Robot compatible

  • Light Sources

    High energy xenon flash lamp

    Dedicated laser for AlphaScreen®/AlphaLISA®/AlphaPlexTM

  • Detectors

    Low-noise photomultiplier tube

    CCD spectrometer

  • Wavelength Selection

    Dual Linear Variable Filter (LVF) Monochromators™

    Linear Variable Dichroic Mirror

    Separates ex & em LVF Monochromators

    Optical filters:

    Ex and em slides hold 4 filters each

    LVF Monochromators + optical filters

    Use one for ex and the other for em 

    UV/Vis absorbance spectrometer:

    Full spectra or 8 distinct wavelengths in < 1 sec/well

  • Optical Filters

    Excitation and emission slides for 4 filters each

  • Optical Path Guides

    Top and bottom: enclosed, free-air optical light path guided by motor-driven mirrors and dichroics

  • Z-Adjustment

    Automatic focal height adjustment (0.1 mm resolution)

  • Spectral Range
    Filters 240 - 750 nm or 240 - 900 nm for FI, FP, TRF
    240 - 750 nm for LUM
    LVF Monochromators™ 320 - 850 nm for FI
    320 - 750 nm for LUM
    Linear Variable Dichroic 340 - 740 nm for FI, LUM
    Spectrometer 220 - 1000 nm for ABS







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